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Pharmacological agents that act to dilate arterioles would thus be inappropriate because at rest they may divert blood from underperfused into healthy vascular regions on account of redundant arteriolar dilation. The resulting “steal effect” could provoke an anginal attack. (3)
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This situation may have implications for drug safety and efficacy, which may need to be addressed and assessed in a marketing application for an ODT33.
Chloroquine and quinine accumulate within the acidic vacuoles of blood schizonts and inhibit polymerization of heme, the latter substance being toxic for the schizonts. Antimalarial drug choice takes into account tolerability and plasmodial resistance. Tolerability. The first available antimalarial, quinine, has the smallest therapeutic margin.

 

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