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Furthermore, gaseous or volatile agents can be administered by inhalation with the goal of alveolar absorption and systemic effects (e.g., inhalational anesthetics). Aerosols are formed when a drug solution or micronized powder is converted into a mist or dust, respectively. In conventional sprays (nebulizer), the air blast required for aerosol formation is generated by the stroke of a pump.
Combination regimens are designed in accordance with substancespecific development of resistance and pharmacokinetic parameters (CNS penetrability, “neuroprotection,” dosing frequency). Disinfection denotes the inactivation or killing of pathogens (protozoa, bacteria, fungi, viruses) in the human environment.

 

Dihydralazine and minoxidil (via its sulfate-conjugated metabolite) dilate arterioles and are used in antihypertensive therapy. They are, however, unsuitable for monotherapy because of compensatory circulatory reflexes. The mechanism of action of dihydralazine is unclear. Minoxidil probably activates K+ channels, leading to hyperpolarization of smooth muscle cells.
Like ASA, these substances have analgesic, antipyretic, and antiinflammatory activity. In contrast to ASA, they inhibit cyclooxygenase in a reversible manner. Moreover, they are not suitable as inhibitors of platelet aggregation. Since their desired effects are similar, the choice between NSAIDs is dictated by their pharmacokinetic behavior and their adverse effects.

 

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