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Furthermore, gaseous or volatile agents can be administered by inhalation with the goal of alveolar absorption and systemic effects (e.g., inhalational anesthetics). Aerosols are formed when a drug solution or micronized powder is converted into a mist or dust, respectively. In conventional sprays (nebulizer), the air blast required for aerosol formation is generated by the stroke of a pump.
Dihydralazine and minoxidil (via its sulfate-conjugated metabolite) dilate arterioles and are used in antihypertensive therapy. They are, however, unsuitable for monotherapy because of compensatory circulatory reflexes. The mechanism of action of dihydralazine is unclear. Minoxidil probably activates K+ channels, leading to hyperpolarization of smooth muscle cells. |
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