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In lieu of epinephrine, the vasopressin analogue felypressin can be used as an adjunctive vasoconstrictor (less pronounced reactive hyperemia, no arrhythmogenic action, but danger of coronary constriction). Vasoconstrictors must not be applied in local anesthesia involving the appendages (e. g. , fingers, toes).
The high analgesic effectiveness of xenobiotic opioids derives from their affinity for receptors normally acted upon by endogenous opioids (enkephalins, ?-endorphin, dynorphins; A). Opioid receptors occur in nerve cells. They are found in various brain regions and the spinal medulla, as well as in intramural nerve plexuses that regulate the motility of the alimentary and urogenital tracts. |
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