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In order to restore a euthyroid state, two therapeutic principles can be applied in Graves’ disease: a) monotherapy with a thioamide with gradual dose reduction as the disease abates; b) administration of high doses of a thioamide with concurrent administration of thyroxine to offset diminished hormone synthesis.
Because it is well absorbed, ketoconazole is available for oral administration. Adverse effects are rare; however, the possibility of fatal liver damage should be noted. Remarkably, ketoconazole may inhibit steroidogenesis (gonadal and adrenocortical hormones). Fluconazole and itraconazole are newer, orally effective triazole derivatives.

 

If bacteria multiply faster than the body’s defenses can destroy them, infectious disease develops with inflammatory signs, e. g. , purulent wound infection or urinary tract infection. Appropriate treatment employs substances that injure bacteria and thereby prevent their further multiplication, without harming cells of the host organism (1).
These drugs are eliminated within minutes after being adminstered, irrespective of the duration of anesthesia. The mechanism of action of inhalational anesthetics is unknown. The diversity of chemical structures (inert gas xenon; hydrocarbons; halogenated hydrocarbons) possessing anesthetic activity appears to rule out involvement of specific receptors.

 

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