Drug Name Lasix

It is the drug of choice in the treatment of angina pectoris attacks. For this purpose, it is administered as a spray, or in sublingual or buccal tablets for transmucosal delivery. The onset of action is between 1 and 3 min. Due to a nearly complete presystemic elimination, it is poorly suited for oral administration.
Mechanism of action. Na+-channel blocking antiarrhythmics resemble most local anesthetics in being cationic amphiphilic molecules (exception: phenytoin). Possible molecular mechanisms of their inhibitory effects are outlined in more detail. Their low structural specificity is reflected by a low selectivity towards different cation channels.

 

For instances, morphine (p. 210), given in the appropriate dose, affords excellent pain relief by influencing nociceptive pathways in the CNS. In excessive doses, it inhibits the respiratory center and makes apnea imminent. The dose dependence of both effects can be graphed in the form of dose-response curves (DRC).
The axonal processes of hypothalamic neurons project to the neurohypophysis, where they store the nonapeptides vasopressin (= antidiuretic hormone, ADH) and oxytocin and release them on demand into the blood. Therapeutically (ADH, p. 64, oxytocin, p. 126), these peptide hormones are given parenterally or via the nasal mucosa.