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In various disease states (organ malfunctions), drugs are employed with the intention of normalizing susceptible organ functions. To understand the biological effects of substances capable of inhibiting or exciting sympathetic or parasympathetic nerves, one must first envisage the functions subserved by the sympathetic and parasympathetic divisions (A, Responses to sympathetic activation).
Antidotes for cyanide poisoning (A). Cyanide ions (CN-) enter the organism in the form of hydrocyanic acid (HCN); the latter can be inhaled, released from cyanide salts in the acidic stomach juice, or enzymatically liberated from bitter almonds in the gastrointestinal tract. The lethal dose of HCN can be as low as 50 mg.

 

Since they may cause mucosal damage, their use should be short-term.
Hypertension infrequently results from another disease, such as a catecholamine- secreting tumor (pheochromocytoma); in most cases the cause cannot be determined: essential (primary) hypertension. Antihypertensive drugs are indicated when blood pressure cannot be sufficiently controlled by means of weight reduction or a lowsalt diet.

 

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