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Presumably, amantadine blocks a channel protein in the viral coat that permits influx of protons; thus, “uncoating” is prevented. Moreover, amantadine inhibits viral maturation. The drug is also used prophylactically and, if possible, must be taken before the outbreak of symptoms. It also is an antiparkinsonian.
(3) they permit binding of heparin to its antidote, protamine (polycationic protein from salmon sperm). If protamine is given in heparin-induced bleeding, the effect of heparin is immediately reversed. For effective thromboprophylaxis, a low dose of 5000 IU is injected s. c. two to three times daily.

 

Desflurane is a close structural relative of isoflurane, but has low lipophilicity that permits rapid induction and recovery as well as good control of anesthetic depth. Substances from different chemical classes suspend consciousness when given intravenously and can be used as injectable anesthetics (B).
Because of its high binding affinity, the lead ion displaces Ca2+ from its bond. The lead-containing chelate is eliminated renally. Nephrotoxicity predominates among the unwanted effects. Na3Ca-Pentetate is a complex of diethylenetriaminopentaacetic acid (DPTA) and serves as antidote in lead and other metal intoxications.

 

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