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Intraocular pressure rises, which must be taken into account during eye surgery. In skeletal muscle fibers whose motor nerve has been severed, ACh receptors spread in a few days over the entire cell membrane. In this case, succinylcholine would evoke a persistent depolarization with contracture and hyperkalemia.
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Upon electrical excitation, a characteristic change occurs in membrane potential— the action potential (AP). Its underlying cause is a sequence of transient ionic currents. During rapid depolarization (Phase 0), there is a short-lived influx of Na+ through the membrane. A subsequent transient influx of Ca2+ (as well as of Na+) maintains the depolarization (Phase 2, plateau of AP).
Because disintegration of the tablet and dissolution of the drug take time, absorption will occur mainly in the intestine (A, track 2). In the case of a solution, absorption starts in the stomach (A, track 3). For acid-labile drugs, a coating of wax or of a cellulose acetate polymer is used to prevent disintegration of solid dosage forms in the stomach.

 

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