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Intraocular pressure rises, which must be taken into account during eye surgery. In skeletal muscle fibers whose motor nerve has been severed, ACh receptors spread in a few days over the entire cell membrane. In this case, succinylcholine would evoke a persistent depolarization with contracture and hyperkalemia.
Upon electrical excitation, a characteristic change occurs in membrane potential— the action potential (AP). Its underlying cause is a sequence of transient ionic currents. During rapid depolarization (Phase 0), there is a short-lived influx of Na+ through the membrane. A subsequent transient influx of Ca2+ (as well as of Na+) maintains the depolarization (Phase 2, plateau of AP). |
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