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O2 demand falls because of the ensuing decrease in the two variables that determine systolic wall tension (afterload): ventricular filling volume and aortic blood pressure. Calcium antagonists (B) decrease O2 demand by lowering aortic pressure, one of the components contributing to afterload.
Therefore, the thyroid increases in size. In addition, intrathyroid depletion of iodine stimulates growth. Because of the negative feedback regulation of thyroid function, thyroid activation can be inhibited by administration of T4 doses equivalent to the endogenous daily output (approx. 150 ?g/d). Deprived of stimulation, the inactive thyroid regresses in size.

 

Like other opioids (hydromorphone, meperidine, pentazocine, codeine), morphine is rapidly eliminated, limiting its duration of action to approx. 4 h. To maintain a steady analgesic effect, these drugs need to be given every 4 h. Frequent dosing, including at nighttime, is a major inconvenience for chronic pain patients.
Amantadine (C) specifically affects the replication of influenza A (RNA) viruses, the causative agent of true influenza. These viruses are endocytosed into the cell. Release of viral DNA requires protons from the acidic content of endosomes to penetrate the virus.

 

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