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A new dosage form allows a manufacturer to extend market exclusivity, unique product differentiation, value-added product line extension, and extend patent protection, while offering its patient population a more convenient dosage form. This leads to increased revenue, while also targeting underserved and under-treated patient populations23.
The probable cause of rheumatoid arthritis is a pathological reaction of the immune system. This malfunction can be promoted or triggered by various conditions, including genetic disposition, age–related wear and tear, hypothermia, and infection.

 

Peptidases are also of pharmacological interest because they are responsible for the formation of highly reactive cleavage products (fibrin, p. 146) and potent mediators (angiotensin II, p. 124; bradykinin, enkephalin, p. 210) from biologically inactive peptides.
Drugs having ability to diffuse and partition into the epithelium of the upper GIT (log P > 1, or preferable > 2); and those able to permeate oral mucosal tissue are considered ideal for ODT formulations. Patients who concurrently take anticholinergic medications may not be the best candidates for these drugs.

 

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