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Methylations are catalyzed by a family of relatively specific methyltransferases involving the transfer of methyl groups to hydroxyl groups (Omethylation as in norepinephrine [noradrenaline]) or to amino groups (Nmethylation of norepinephrine, histamine, or serotonin). In thio compounds, desulfuration results from substitution of sulfur by oxygen (e. g. , parathion).
Decarboxylation also takes place in peripheral organs where dopamine is not needed, likely causing undesirable effects (tachycardia, arrhythmias resulting from activation of ?1-adrenoceptors [p. 114], hypotension, and vomiting).

 

Rarely life-threatening, poisoning with atropine is characterized by the following peripheral and central effects: Peripheral: tachycardia; dry mouth; hyperthermia secondary to the inhibition of sweating. Although sweat glands are innervated by sympathetic fibers, these are cholinergic in nature.
In coronary spasm, calcium antagonists can induce spasmolysis and improve blood flow. ?-Blockers (C) protect the heart against the O2-wasting effect of sympathetic drive by inhibiting ?-receptormediated increases in cardiac rate and speed of contraction. Uses of antianginal drugs (D). For relief of the acute anginal attack, rapidly absorbed drugs devoid of cardiodepressant activity are preferred.

 

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