Drug Name Lasix

Direct Parasympathomimetics. The choline ester, carbachol, activates M-cholinoceptors, but is not hydrolyzed by AChE. Carbachol can thus be effectively employed for local application to the eye (glaucoma) and systemic administration (bowel atonia, bladder atonia).
For slowly eliminated drugs, which tend to accumulate extensively (phenprocoumon, digitoxin, methadone), the optimal plasma level is attained only after a long period. Here, increasing the initial doses (loading dose) will speed up the attainment of equilibrium, which is subsequently maintained with a lower dose (maintenance dose).

 

Since benzodiazepine intoxication may become life-threatening only when other central nervous depressants (ethanol) are taken simultaneously and can, moreover, be treated with specific benzodiazepine antagonists, the benzodiazepines should be given preference as sleep remedies over the all but obsolete barbiturates.
The decarboxylation of methyldopa competes for a portion of the available enzymatic activity, so that the rate of conversion of L-dopa to NE (via dopamine) is decreased. The false transmitter ?-methyl-NE can be stored; however, unlike the endogenous mediator, it has a higher affinity for ?2- than for ?1-receptors and therefore produces effects similar to those of clonidine.