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The presence of a continuous phospholipid layer means that squamous epithelia will permit passage of lipophilic drugs only, i.e., agents capable of diffusing through phospholipid membranes, with the epithelial thickness determining the extent and speed of absorption.
Only in the case of status epilepticus (a succession of several tonic-clonic seizures) is acute anticonvulsant therapy indicated — usually with benzodiazepines given i. v. or, if needed, rectally.

 

Magnesium sulfate, given i.v., is a useful alternative when ?-mimetics are contraindicated, but must be carefully titrated because its nonspecific calcium antagonism leads to blockade of cardiac impulse conduction and of neuromuscular transmission.
The substances listed below are useful as antibacterial drugs because they do not affect human cells. Gyrase inhibitors. The enzyme gyrase (topoisomerase II) permits the orderly accommodation of a ~1000 ?mlong bacterial chromosome in a bacterial cell of ~1 ?m. Within the chromosomal strand, double-stranded DNA has a double helical configuration.

 

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