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These dosage forms may be suitable for the oral delivery of drugs such as protein and peptide-based therapeutics that have limited bioavailability when administered by conventional tablets. These products usually degrade rapidly in the stomach. Should next generation drugs be predominantly protein or peptide based, tablets may no longer be the dominant format for dosing such moieties.
HCG, human chorionic gonadotropin, from the urine of pregnant women, acts like LH. Anabolics are testosterone derivatives (e. g. , clostebol, metenolone, nandrolone, stanozolol) that are used in debilitated patients, and misused by athletes, because of their protein anabolic effect.

 

Absorption of such drugs proceeds rapidly, because the absorbing surface is greatly enlarged due to the formation of the epithelial brush border (submicroscopic foldings of the plasmalemma). The absorbability of a drug is characterized by the absorption quotient, that is, the amount absorbed divided by the amount in the gut available for absorption.
In order to restore a euthyroid state, two therapeutic principles can be applied in Graves’ disease: a) monotherapy with a thioamide with gradual dose reduction as the disease abates; b) administration of high doses of a thioamide with concurrent administration of thyroxine to offset diminished hormone synthesis.

 

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