Drug Name Zyprexa

Hydrophilic drugs undergo rapid elimination. If a lipophilic drug, because of its chemical nature, cannot be converted into a polar product, despite having access to all cells, including metabolically active liver cells, it is likely to be retained in the organism. The portion filtered during glomerular passage will be reabsorbed from the tubules.
A given sustance does not necessarily behave as an agonist or antagonist at all receptor subtypes, but may act as an agonist at one subtype and as a partial agonist/ antagonist or as a pure antagonist (p. 214) at another. The abuse potential is also determined by kinetic properties, because development of dependence is favored by rapid build-up of brain concentrations.

 

The enhanced risk of vascular disease (coronary stenosis, myocardial infarction, and central and peripheral ischemic disorders, such as stroke and intermittent claudication) is likely to be a consequence of chronic exposure to nicotine.
Chronic use of neuroleptics can, on occasion, give rise to hepatic damage associated with cholestasis. A very rare, but dramatic, adverse effect is the malignant neuroleptic syndrome (skeletal muscle rigidity, hyperthermia, stupor) that can end fatally in the absence of intensive countermeasures (including treatment with dantrolene.