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Various drugs can lower seizure threshold, notably certain neuroleptics, the tuberculostatic isoniazid, and ?-lactam antibiotics in high doses; they are, therefore, contraindicated in seizure disorders. Glutamate receptors comprise three subtypes, of which the NMDA subtype has the greatest therapeutic importance. (N-methyl-D-aspartate is a synthetic selective agonist. )
However, because it is poorly absorbed (<50%) and therefore causes more extensive damage to the gut microbial flora (side effect: diarrhea), it should be given only by injection. A still broader spectrum (including Pseudomonas bacteria) is shown by carboxypenicillins (carbenicillin, ticarcillin) and acylaminopenicillins (mezclocillin, azlocillin, piperacillin).

 

Nonsteroidal anti-inflammatory drugs, such as indomethacin and phenylbutazone, are also effective. In severe cases, glucocorticoids may be indicated. Effective prophylaxis of gout attacks requires urate blood levels to be lowered to less than 6 mg/100 mL. Diet.
Overdosage may induce hypercalcemia with deposits of calcium salts in tissues (particularly in kidney and blood vessels): calcinosis. The polypeptide parathormone is released from the parathyroid glands when plasma Ca2+ level falls. It stimulates osteoclasts to increase bone resorption; in the kidneys, it promotes calcium reabsorption, while phosphate excretion is enhanced.

 

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