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Apart from interference with transmembrane cation fluxes (via ion channels and pumps), a lithium effect of major significance appears to be membrane depletion of phosphatidylinositol bisphosphates, the principal lipid substrate used by various receptors in transmembrane signalling.
Because host DNA synthesis remains unaffected, adverse effects do not include bone marrow depression. Acyclovir is eliminated unchanged in urine (t1/2 ~ 2. 5 h). Valacyclovir, the L-valyl ester of acyclovir, is a prodrug that can be administered orally in herpes zoster infections. Its absorption rate is approx. twice that of acyclovir. |
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